The number of Turkish citizens entering the U.S. for their studies is growing more rapidly than almost any other group. The purpose of the current study was to investigate how acculturation factors affect psychological adaptation of Turkish students in the U.S. One hundred and twenty-four Turkish students participated in the study. Regression analyses revealed that social support and self-esteem were predictors of psychological adjustment. Implications suggest that Turkish students, as with other international students as previous research has suggested, should have a strong network of both co-national students and other social connections.