This study explored the biography-driven approach to teaching culturally and linguistically diverse students in science education. Biography-driven instruction (BDI) embraces student diversity by incorporating students' sociocultural, linguistic, cognitive, and academic dimensions of their biographies into the learning process (Herrera in "Biography-driven culturally responsive teaching." Teachers College Press, New York, 2010). Strategies have been developed (Herrera, Kavimandan and Holmes in "Crossing the vocabulary bridge: differentiated strategies for diverse secondary classrooms." Teachers College Press, New York, 2011) that provide teachers with instructional routines that facilitate BDI. Using systematic classroom observations we empirically demonstrate that these activate, connect, affirm, strategies are likely to be effective in increasing teachers' biography-driven practices. Implications for theory and practice are discussed.