This descriptive study examined observational data collected in inclusive classrooms from six schools that were operating schoolwide inclusive policies and practices. Illustrative evidence of classroom practices supporting learning and participation of all students, including students with significant disabilities, adds to an understanding of structural methods supporting inclusion, as well as insights into instructional strategies and approaches used to support inclusive practices. Supports for participation were observed in several domains: (a) instructional staffing arrangements and roles, (b) methods of instructional groupings, (c) peer-supported learning, and (d) access to core academic curriculum. Supports for learning were also observed, including (a) universal design for learning, (b) behavioral interventions, and (c) accommodations and modifications. The results are discussed in relation to implementation of essential components of inclusive classrooms and the issues the field is facing with regard to effective practices leading to student learning and inclusion within classrooms and throughout schools.