Both the Elementary and Secondary Education Act of 2001 (No Child Left Behind) and the Individuals with Disabilities Education Improvement Act of 2004 show a public policy preference for the use of interventions that are supported by scientific evidence of their efficacy. At the same time, parents of children with Autism Spectrum Disorders (ASD) are frustrated by the lack of effective treatments and often resort to complementary and alternative medical (CAM) treatments to treat the symptoms of their child's ASD. Many of these treatments have little or no evidence of efficacy. This article reviews the current state of many CAMs and addresses the evidence that supports or fails to support their efficacy as a treatment of ASD and their adoption in special education practices. It also discusses some recommendations for improving the state of evidence for CAMs used with individuals with ASD.