This review of the research literature on the interaction between humans and computers discusses how man machine systems can be utilized effectively in the learning-teaching process, especially in secondary education. Beginning with a definition of man machine systems and comments on the poor quality of much of the computer-based learning material currently available, the discussion focuses on how to make optimal use of the interaction between computers and students. The discussion includes definitions and concepts of this interaction, as well as examples of the use of artificial intelligence for computer-assisted instruction in problem-solving and mathematics. Also identified are four types of interactions between humans and machines and criteria and recommendations considered important for effective interaction between students and computers. Specific uses of the computer in various disciplines, teacher attitudes towards computers, and the use of videotex are also discussed. A synthesis of these issues is provided, followed by three recommendations for making effective use of computer interactions in education in the future and an outline of some of the issues that should be considered when designing the user interface for students. A 33-item bibliography/reference list is appended. (DJR)