With clinical purposes in mind, a review of the proximaldistal opposition is carried out in order to define a universal parameter of variability in semiotic procedures. By taking into consideration different--although notionally inter-related--senses of the proximaldistal opposition, a cluster of semiotic properties is proposed, which initially permits one to characterize dimensions of variability in the form and use of gestures. The subsequent and central aim of this paper is, however, to demonstrate that the same, or homologous, properties can also serve to characterize variability in the use of language, by assuming a basic connection between gesturing and linguistic behaviour. The main focus of interest and the starting point for reflections are communicative impairments as manifested in apraxia and aphasia. (Contains 3 tables.)