InterActive Physiology (IAP) is one of a new generation of anatomy and physiology learning aids with a broader range of sensory inputs than is possible from a static textbook or moderately dynamic lecture. This best-selling software has modules covering the muscular, respiratory, urinary, cardiovascular, and nervous systems plus a module on fluids and electrolytes. IAP and similar software may make a critical contribution to the success of students by its unique ability to demonstrate the visual-spatial aspects of some of anatomy and physiology's most complex concepts. In this article, the authors propose to test two hypotheses: (1) Supplemental use of IAP will increase student exam performance; and (2) Students will find the software a useful adjunct regardless of effect on performance. Two hundred forty-six students (150 from anatomy and 96 from anatomy and physiology) participated in the experiment. Based on the results, the hypothesis that supplemental use of IAP software will improve student exam performance is rejected, while the hypothesis that students find value in the IAP modules regardless of any improvements in test scores is verified. (Contains 3 tables.)