This exploratory study investigated the social and affective concerns of 280 high-ability students in Grades 5 through 12 who participated in a summer residential program. Content analysis of responses from an open-ended survey indicated that high-ability adolescents expressed concerns regarding feelings and emotions, future aspirations, and relationships. How these social and affective concerns differed across gender, age, and among U.S. students, international students, and Native American subgroups were also investigated. Boys would like to discuss puberty and maturity more than girls; students in early adolescence cared about feelings, whereas those in late adolescence wanted to discuss future aspirations; Native American students had similar concerns to those of other students; however, Diné students were concerned about personal issues and bullying. These findings provide researchers and educators in the field of gifted education with new perspectives regarding social and affective concerns of high-ability students.