The United States continues to have one of the highest teen birth rates in the developed world, and adolescent rates of sexually transmitted infections (STIs) are also high. These factors highlight the need to identify effective evidence-based programs to improve adolescent reproductive health. This brief synthesizes findings from 118 experimental evaluations of 100 program models. These were evaluations measuring reproductive health of youth and adolescents to determine how frequently these programs work to improve behavioral sexual outcomes such as sexual initiation and activity, number of sexual partners, anal/oral sex, sex under the influence of drugs/alcohol, condom and contraceptive use, sexually transmitted infections (STIs), and pregnancies or births. These programs used a range of program approaches and served a variety of populations in many different settings. [Additional support was provided by the JPB Foundation.]