Thanks to advanced developments in wireless technology, learners can now utilize digital learning websites at anytime and anywhere. Mobile learning captures more and more attention in the wave of digital learning. Evolving use of knowledge management plays an important role to enhance problem solving skills. Recently, innovative approaches for integrating knowledge management into practical teaching activities have been ignored. This is the first study to focus the design of a mobile knowledge management learning system that encourages learners to acquire, store, share, apply and create knowledge. When learners use different mobile devices to learn, larger screens perform better than smaller ones in the task performance and system working quality. Analyzed by learning achievements, the experimental group has a rather significant effect in adopting mobile knowledge management learning system than the control group of traditional classroom lectures. After evaluating the system acceptance by questionnaire survey, the experiment results indicate that (1) perceived easy to use can positively predict perceived usefulness by learners, (2) perceived easy to use and perceived usefulness can positively predict behavioral intention of the system acceptance. Perceived usefulness is the key factor for learners' willingness to be guided through the system's learning process. (Contains 9 tables and 3 figures.)