Larger class sizes are often the solution to the greater enrollments and fewer resources that many colleges and universities face today. These large classes present special challenges to courses that were typically and most effectively taught in small, interactive and open settings. A "Classroom Response System" (CRS), an instructional tool that promotes student interaction by collecting, tabulating and displaying student responses to questions, can address this challenge. A survey of student attitudes in a large Sexual Health course indicate that students enjoy using a CRS and think it contributes positively to their learning experience. (Contains 1 table.)