This article discusses the professional dimension of making technology-enhanced learning (TEL) a part of European higher educational practices. In order to position the article in a European context, three of the most important European research Networks of Excellence (NoEs) aimed at understanding, developing, and implementing TEL and educational technologies are described. Using a meta-design inspired approach proposed by Fischer (2007), it is proposed that teachers through professional development can become designers of their own learning activities and develop the pedagogical tools they need for teaching with technologies in the 21st century.