This study assessed the association between perceived health, fatigue, positive and negative affect, handgrip strength, objectively measured physical activity, body mass index, and self-reported functional limitations, assessed 6 months later, among 11 centenarians (age = 102 plus or minus 1). Activities of daily living, assessed 6 months prior to assessment of functional limitations, were also included in the model. Handgrip strength, positive affect, and self-rated current health were associated with higher functioning, expressed as either global, upper body, or lower body functioning (r greater than 0.60). Objectively measured physical activity was inversely related to the aforementioned measures of functioning. Thus, physical health as assessed by handgrip strength, but not by physical activity, is associated with better functioning in centenarians. (Contains 2 tables.)