Drawing on the theory of planned behaviour, this study examines the direct and indirect effects of knowledge gained from a formal entrepreneurship education programme on an individual's entrepreneurial intentions (EI). It tracks the changes in students' entrepreneurial knowledge (EK), perceptions of desirability of, and self-efficacy in, engaging in entrepreneurship and the impact of those changes on students' EI upon completion of an entrepreneurship course. It uses longitudinal survey data of 245 business students in a Philippine university. Using cross-lagged panel method and partial-least squares-based structural equation modelling, the study builds and tests the measurement and structural models to examine the hypothesised interactions of EK, perceived desirability of, self-efficacy towards entrepreneurship, and EI. The findings underscore the importance of developing knowledge to nurture students' self-confidence and attitudinal propensity to engage in entrepreneurship.