Migrant and seasonal farmworkers are typically Spanish-speaking, Latino immigrants with limited formal education and low literacy skills and, as such, are a vulnerable population. We describe the development of the "Pesticides and Farmworker Health Toolkit", a pesticide safety and health curriculum designed to communicate to farmworkers pesticide hazards found in their working environments. Using evidence-informed principles, the "Toolkit" curriculum for low-literacy, Latino farmworkers and its developmental process described herein serve as an innovative and useful model for Extension programming with non-traditional audiences.