Teaching mindfulness to parents as well as adolescents through a family-centered intervention approach can have a positive impact on the parent-youth relationship. In mindful parenting, caretakers are aware of their own feelings and emotions, and interact with their adolescents in a mindful way by demonstrating emotional awareness, attentive listening, nonjudgment, self-regulation, and compassion. This chapter discusses the need for family-centered mindfulness approaches in adolescence. It introduces the Mindfulness-enhanced Strengthening Families Program, describes specific program activities and their theoretical rationale, and presents initial empirical evidence from pilot studies of the intervention.