Background: Research on strategies for addressing multiple health-related behaviors (HRBs) in one intervention are needed because resources are sparse and clarification is needed regarding the relationship between multiple HRBs. Purpose: Determine undergraduate students' health behavior co-occurring pairs of smoking cigarettes (SC), alcohol consumption (AC), smoking marijuana (SM), physical activity (PA), and fruit and vegetable consumption (FV) and identify the characteristics of the pairs. Methods: Nine hundred and twenty-eight undergraduate students enrolled in a health and wellness course were surveyed. A combination of phi statistical test and logistic regression identifies behavior pairs and the variations of paired behaviors by sociodemographic characteristics. Results: Five of the 10 pair combinations had a relationship (P < 0.01): SC&AC, AC&SM, SC&SM, SC&PA, and PA&FV. Males were more likely to practice risky SC&AC, SC&SM, and AC&SM behaviors, and females were more likely to practice risky PA&FV. Discussion: Investigation into the co-occurrence of HRBs pairs provides further insight into the unique associations among 5 Healthy Campus objectives. Translation to Health Education Practice: Health educators have insight into the behaviors to include in one intervention designed for paired behaviors, knowledge of how to prioritize interventions, and which students to target.