The aim of this case study was to examine pre-service science teachers' (PSTs) perceptions of their Technological Pedagogical Content Knowledge (TPACK) development after creating digital stories based on science topics drawn from the national curriculum. A total of 21 PSTs enrolled in Introduction to Computers II participated in the study. Data were collected through a demographics questionnaire, a TPACK diagram, an open-ended questionnaire, interviews, and observations. During the study, feedback was provided to participants during each step of the digital storytelling process: writing the stories, finding related pictures, matching the pictures to the stories; and preparing the digital files. The PSTs reported that their technological knowledge, pedagogical knowledge, and content knowledge improved during the course.