This study examines whether incorporating a multidimensional perspective to the study of the relation between cultural adaptation and academic attitudes among Latinas/os in the United States can clarify this relation. Hypotheses about the relation between cultural adaptation and academic attitudes were examined using data provided by U.S. Latina/o high school students. Findings suggest that enculturation and acculturation moderate each other's effects on academic attitudes and that this moderation effect varies across cultural adaptation dimensions.