Special educators often become frustrated when, despite their best efforts to help students attain their goals and maximize their achievement, their instruction does not result in the desired outcomes. With so many practices being promoted on the Internet, during in-service trainings, at professional conferences, and by their colleagues, it can be difficult to know what to try and who to trust. Evidence-based practices can be trusted to work because they have been shown to be effective by a body of research studies that meet rigorous criteria related to research design, quality, quantity, and effect size. In this article the authors provide an overview of sources of evidence-based practices and specific practices shown to be evidence-based for students with, and at-risk for, disabilities. To guide special educators in their identification and application of evidence-based practices, a 10-step framework for implementing evidence-based practices effectively is provided. (Contains 1 table and 2 figures.)