This article presents findings from an investigation of the overall effectiveness of Michigan's Freedom to Learn (FTL) One-to-One initiative. The major goal of the FTL initiative was to help students to gain 21st century knowledge and skills while increasing their learning and achievement through the integration of over 20,000 laptop computers with comprehensive teacher professional development. This study used a mixed-methods descriptive and quasi-experimental design. Data were collected with validated observation and survey instruments. The findings reveal greater use of research-based best practices in FTL classrooms and greater teacher confidence to integrate technology as compared to normative data. FTL students performed as well as control students yet demonstrated greater 21st century knowledge and skills. (Contains 8 tables and 4 figures.)