This manual, which is part of a series of training and information materials for managers and trainers of health staff in developing countries, is designed to assist individuals responsible for designing national health learning materials. The introduction explains the manual's purpose, organization, and use and discusses the importance of instructional design. Each of the manual's 12 chapters presents one design strategy and includes a learning objective, health-related examples taken from various sources to illustrate different ways of using the design strategy being discussed, summary boxes highlighting the chapter's main points, and practice activities. The individual chapters are organized into five sections as follows: learning (how people learn); focusing the learner's attention (learning objectives, advance organizers, margin call-outs, and visual signals); organizing the learning (verbal signals, summaries, and examples); integrating the learning (practice activities, feedback, and inserted questions); and putting it all together (using design strategies). A glossary and brief list of suggested readings are included. (MN)