This document notes that a recent threat to American's youth is the risk of infection from the human immunodeficiency virus (HIV). It views youth at high risk for alcohol or other drug use as also being, in all probability, at highest risk for exposure to HIV, and suggests that programs set up to prevent adolescents from becoming involved with alcohol or other drugs can apply many of the same principles to stopping the spread of HIV. The information presented in this technical report was selected to inspire organizations to join in the prevention effort, to provide an outline for developing or adding to a program, and to direct staffs to a variety of resources. It presents recent statistics on the prevalence of HIV infection among adolescents, the epidemiology of the disease among this age group, and groups at highest risk for infection. The section on adolescents at highest risk focuses on ethnic and racial youth, adolescent homosexual and bisexual males, adolescent females, runaway and homeless youth, delinquent and incarcerated youth, and sexually abused youth. The document provides a brief overview of methods for starting a program and building community support. Strategies found effective in intervening with youth at risk for HIV exposure are described, references are provided, and a list of national resources is appended. (NB)