This report reports activities of the Regional Information Exchange (RIE) program under the National Institute on Disability and Rehabilitation Research's Knowledge Dissemination and Utilization Program. An overview compares the RIE program with a National Diffusion Network unit--the Joint Dissemination Review Panel, which also focuses on validating effective programs and encouraging dissemination. The operational procedures of five regional RIEs which follow centrally etablished funding priorities are described. Issues are discussed concerning: (1) the nomination and validation of exemplary programs; (2) RIE priorities; (3) dissemination and utilization activities; (4) RIE evaluation procedures; (5) the program's regional configuration; and (6) the relationship of the program's activities to the parent organization's broad research and dissemination mission. Differences in approach among the RIEs are stressed, with two RIEs emphasizing rigorous, systematic, research based evaluation and validation; two emphasizing proactive, hands-on, organizational capacity building; and one focusing on a specific topical area. Recommendations include: RIEs should consider limiting the priorities addressed; site visits to applicant programs should be part of validation activities; and establishment of a national RIE component should be considered. (DB)