This paper cites the incidence of substance abuse among individuals with physical disabilities, especially among students in postsecondary education. The paper notes that differences in drug use patterns depend on whether the disability is congenital or trauma-generated and describes differences in the type of abuse depending on whether the abuse problem came before the disability or vice versa. The accessibility of drugs, the atypical social experiences of individuals with disabilities, societal enabling and entitlement of drug use among persons with disabilities, and the lack of identification of substance abusers are discussed. Strategies to address substance abuse among persons with disabilities are identified, including professional and student education, screening programs, an intervention team approach, and support groups. The paper concludes by urging departments for disabled student services in postsecondary institutions to incorporate substance abuse policy and procedures into their spectrum of issues addressed. (JDD)