This publication reproduces 87 frames from a computer assisted instruction program designed as a course for library science students or as a refresher course for experienced reference librarians. It is noted that the program itself is run on an Apple II microcomputer and takes about 45 minutes to complete. The frames reproduced present information on: (1) the nature and scope of the lessons; (2) lesson objectives; (3) the definition, characteristics, and uses of reference books; (4) types of general reference books, including those which contain the needed information (dictionaries, encyclopedias, handbooks, biographical dictionaries, atlases, and gazetteers) and those which tell the user where the information can be found (indexes and bibliographies); and (5) science reference tools, including specific dictionaries, encyclopedias, handbooks, biographical dictionaries, indexes, and bibliographies. The frames also show how multiple-choice and short answer exercises and progress reports are provided periodically throughout the instruction program. Five specific reference questions in the areas of science and technology are included among the exercises. An introduction to the publication includes an index to the types of frames used in the instruction program. (ESR)