This manual serves as a resource for Design Labs in the Unified Sciences and Mathematics for Elementary Schools (USMES) program. A Design Lab is not a customary "shop" where students receive training in woodworking, metalworking, and other crafts. Instead, when a construction need arises during USMES units, a Design Lab becomes the central location for tools, materials, and working space for students to plan and build according to their theories, make and benefit from mistakes, and develop improved designs. Section I provides general information, focusing on the USMES Design Lab concept, tone of student activities, safety considerations, and what students have made in Design Labs. Section II, focusing on setting up Design Labs, discusses planning a Lab, forms of Design Labs (in-class Labs, portable Labs, separate-room Labs), and Design Lab tools and materials. Section III addresses staffing and training, including an overview of staffing/training considerations, Design Lab orientation methods, staffing, and teacher training. Appendices include a bibliography, list of Design Lab "How To" cards, nature of USMES and its resources, tri-wall (three-layered cardboard) ordering information, and Design Lab inventory lists. (Author/JN)