General and specific safety procedures and recommendations for secondary school science laboratories are provided in this guide. Areas of concern include: (1) chemicals (storage, disposal, toxicity, unstable and incompatible chemicals); (2) microorganisms; (3) plants; (4) animals; (5) electricity; (6) lasers; (7) rockets; (8) eye safety and protective eye devices; (9) equipment producing ionizing radiation; and (10) radioisotopes. Pertinent Pennsylvania laws are cited for appropriate areas. An appendix contains various items pertaining to laboratory safety considerations including lists of non-recommended chemicals, carcinogens and their synonyms, lists of radioisotopes and their sources, and rules and regulations of the United States Nuclear Regulatory Commission. (JN)