Educational dissemination is a way to foster changes in educational practice. Peer interaction is a special type of dissemination in which people with certain roles and responsibilities help others with the same or similar roles and responsibilities. This involves teachers helping teachers, principals helping principals, business representatives helping others in business and so forth. The primary purpose of this guide is to describe a regional career education peer assistance model and to share what was learned in creating the model with others wanting to use such a model. The guide is especially aimed at the following groups: (1) career education coordinators at state, intermediate, and local levels; (2) operators of multistate dissemination services such as regional exchanges and vocational curriculum management centers; (3) state dissemination specialists, such as state facilitators, capacity-builders, and talent bank directors; and (4) representatives of labor, business, industry, and government. The guide covers the following topics: model overview; selecting the consultants; promoting the service; training the consultants; making the system work; considerations in establishing peer assistance models; and a review of the literature on peer interaction. (KC)