This resource manual presents numerous techniques for adapting science activities to the visually handicapped student, applicable to introductory biology courses in which microscopes are used extensively in the laboratory. Chapters include information on the following: alternative microscopic viewing techniques, physical models, tactile diagrams, measuring techniques, alternative activities and materials (genetics, bacteria, mapping chromosomes, mitotic indexing, blood typing, osmosis), and other techniques (mathematical problems, lab reports, tactile record sheets, safety considerations, sensors, Sewell embossing, and swail dot inverter). An appendix lists sources of materials and equipment for the visually handicapped. (CS)