This document on the undergraduate laboratory biology course is organized into 4 parts. Part 1 deals with the role of investigation in the undergraduate curricula. Chapters in this section deal with the time for laboratory reform; some special considerations in designing laboratory programs for nonmajors; the appropriate laboratory experiences for the biology major; Teaching and learning through investigation; and the concept, origin and current status of the investigative laboratory. Part 2 is involved with the practice of investigative laboratories. Chapters deal specifically with laboratories in the introductory courses at 4-year colleges and universities; investigative laboratories in advanced courses; investigative laboratories at field stations; and investigative activities in 2-year community colleges. Part 3 describes the laboratory curricula in general, with specific chapters on the laboratory curriculum at Marquette University and undergraduate biology laboratories at Massachusetts Institute of Technology. The fourth and final part deals with helping students learn how to investigate. (For related document see ED 064 112 in RIEOCT72). (HS)